MolNFT v1 · #26471 · protein
Escherichia COLI tyrosyl-tRNA synthetase mutant complexed with L- tyrosine
1WQ4: “Escherichia COLI tyrosyl-tRNA synthetase mutant complexed with L- tyrosine”. X-ray diffraction, 1 ligand (TYR), 4 pockets (best druggability 0.73). MolNFT v1 #26471 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WQ4
- Type
- protein
- Length
- 321 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosyl-tRNA synthetase
- EC
- 6.1.1.1
- UniProt
- P00951
- Ligands
- TYR
- Pockets
- 4 · best druggability 0.73
Structure
x-ray diffraction · 1 distinct chain · 55% helix, 11% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosyl-tRNA synthetase (EC 6.1.1.1) | protein | 321 | 55% helix, 11% strand | P00951 |
Ligands and binding sites
- TYR · Tyrosine · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 416 | 0.73 | 0.84 | 55 | TYR |
| 2 | 153 | 0.44 | 0.75 | 23 | empty |
| 3 | 53 | 0.38 | 0.80 | 15 | empty |
| 4 | 88 | 0.36 | 0.75 | 14 | empty |
Compared structures
- 1WQ4 · Escherichia coli tyrosyl-tRNA synthetase mutant complexed with L-tyrosine · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P00951
- Elsewhere: RCSB PDB 1WQ4 · PDBe 1WQ4 · UniProt P00951
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