MolNFT v1 · #26462 · protein

Crystal structure of hutp, an RNA binding anti-termination protein

1WPT · Hut operon positive regulatory protein: “Crystal structure of hutp, an RNA binding anti-termination protein”. X-ray diffraction, 3 pockets (best druggability 0.62). MolNFT v1 #26462 on GenesisL1: 3D structure, binding sites and…

PDB: 1WPT
Type: protein
Length: 288 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Hut operon positive regulatory protein
UniProt: P10943
Pockets: 3 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 39% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Hut operon positive regulatory protein	protein	144	39% helix, 26% strand	P10943

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	232	0.62	0.81	43	empty
2	65	0.41	0.80	21	empty
3	50	0.32	0.77	15	empty

Interfaces

1 interface between chains.

A–B · 1025 Å² buried · 20 hydrogen bonds · protein-protein

Compared structures

1WPT · Crystal Structure of HutP, an RNA binding anti-termination protein · the same entry in another collection · chain A against A, TM-score 1.00
P10943 · AlphaFold monomer V2.0 prediction for hut operon positive regulatory protein (P10943) · a predicted model of the same protein · chain A against A, TM-score 0.88

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P10943
Elsewhere: RCSB PDB 1WPT · PDBe 1WPT · UniProt P10943

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