MolNFT v1 · #26453 · protein

Methylated form of N-terminal transcriptional regulator domain of escherichia COLI ada protein

1WPK · Ada regulatory protein: “Methylated form of N-terminal transcriptional regulator domain of escherichia COLI ada protein”. Solution nmr, 1 ligand (ZN), 2 pockets (best druggability 0.51). MolNFT v1 #26453 on GenesisL1: 3D structure…

PDB: 1WPK
Type: protein
Length: 146 residues
Chains: 1
Method: solution nmr
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Ada regulatory protein
UniProt: P06134
Ligands: ZN
Pockets: 2 · best druggability 0.51

Structure

solution nmr · 1 distinct chain · 42% helix, 10% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Ada regulatory protein	protein	146	42% helix, 10% strand	P06134

Ligands and binding sites

ZN · Zinc ion · metal · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	118	0.51	0.81	28	empty
2	71	0.48	0.83	14	empty

Modifications

Observed in the structure: 1 modified (methylation).

Compared structures

1WPK · Methylated Form of N-terminal Transcriptional Regulator Domain of Escherichia Coli Ada… · the same entry in another collection · chain A against A, TM-score 1.00
P06134 · AlphaFold monomer V2.0 prediction for bifunctional transcriptional ACTIVATOR/DNA repair… · a predicted model of the same protein · chain A against A, TM-score 0.52

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P06134
Elsewhere: RCSB PDB 1WPK · PDBe 1WPK · UniProt P06134

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