MolNFT v1 · #26434 · protein
Crystal structure of heme oxygenase-2 from synechocystis sp. pcc 6803 in complex with heme
1WOV · Heme oxygenase 2: “Crystal structure of heme oxygenase-2 from synechocystis sp. pcc 6803 in complex with heme”. X-ray diffraction, 1 ligand (HEM), 2 pockets (best druggability 0.81). MolNFT v1 #26434 on GenesisL1: 3D structure…
- PDB
- 1WOV
- Type
- protein
- Length
- 486 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heme oxygenase 2
- EC
- 1.14.99.3
- UniProt
- P74133
- Ligands
- HEM
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 2 distinct chains · 72% helix, 2% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heme oxygenase 2 (EC 1.14.99.3) | protein | 244 | 72% helix, 2% strand | P74133 |
| B | Heme oxygenase 2 (EC 1.14.99.3) | protein | 242 | 72% helix, 2% strand | P74133 |
Ligands and binding sites
- HEM · Protoporphyrin IX containing Fe · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 442 | 0.81 | 0.88 | 49 | HEM |
| 2 | 444 | 0.79 | 0.87 | 51 | HEM |
Interfaces
1 interface between chains.
- A–B · 1547 Ų buried · 25 hydrogen bonds · protein-protein
Compared structures
- 1WOV · Crystal structure of heme oxygenase-2 from Synechocystis sp. PCC 6803 in complex with heme · the same entry in another collection · chain A against A, TM-score 1.00
- P74133 · AlphaFold monomer V2.0 prediction for heme oxygenase 2 (P74133) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P74133
- Elsewhere: RCSB PDB 1WOV · PDBe 1WOV · UniProt P74133
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