MolNFT v1 · #26385 · protein
Crystal structure of PH0066 from pyrococcus horikoshii
1WNF · L-asparaginase: “Crystal structure of PH0066 from pyrococcus horikoshii”. X-ray diffraction, 2 pockets (best druggability 0.29). MolNFT v1 #26385 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WNF
- Type
- protein
- Length
- 648 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- L-asparaginase
- EC
- 3.5.1.1
- UniProt
- O57797
- Pockets
- 2 · best druggability 0.29
Structure
x-ray diffraction · 1 distinct chain · 28% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | L-asparaginase (EC 3.5.1.1) | protein | 324 | 28% helix, 24% strand | O57797 |
Ligands and binding sites
- EDO · 1,2-ethanediol · additive · 5 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 59 | 0.29 | 0.74 | 17 | empty |
| 2 | 52 | 0.25 | 0.73 | 18 | empty |
Interfaces
1 interface between chains.
- A–B · 3351 Ų buried · 51 hydrogen bonds · protein-protein
Compared structures
- 1WNF · Crystal Structure of PH0066 from Pyrococcus horikoshii · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O57797
- Elsewhere: RCSB PDB 1WNF · PDBe 1WNF · UniProt O57797
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