MolNFT v1 · #26306 · protein

Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga maritima R91A mutant

1WL3 · Octoprenyl-diphosphate synthase: “Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga maritima R91A mutant”. X-ray diffraction, 13 pockets (best druggability 0.72). MolNFT v1 #26306 on GenesisL1…

PDB: 1WL3
Type: protein
Length: 555 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Octoprenyl-diphosphate synthase
EC: 2.5.1.11
UniProt: Q9X1M1
Pockets: 13 · best druggability 0.72

Structure

x-ray diffraction · 2 distinct chains · 74% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Octoprenyl-diphosphate synthase (EC 2.5.1.11)	protein	277	75% helix, 1% strand	Q9X1M1
B	Octoprenyl-diphosphate synthase (EC 2.5.1.11)	protein	278	73% helix, 1% strand	Q9X1M1

Pockets

13 pockets found on a 1 Å grid, 9 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	75	0.72	0.96	21	empty
2	53	0.69	0.96	19	empty
3	285	0.69	0.84	32	empty
4	64	0.68	0.95	15	empty
5	252	0.65	0.82	29	empty

Interfaces

1 interface between chains.

A–B · 1776 Å² buried · 16 hydrogen bonds · protein-protein

Compared structures

1WL3 · Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X1M1
Elsewhere: RCSB PDB 1WL3 · PDBe 1WL3 · UniProt Q9X1M1

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