MolNFT v1 · #26065 · protein

Yeast BBC1 SH3 domain, triclinic crystal form

1WDX · Myosin tail region-interacting protein MTI1: “Yeast BBC1 SH3 domain, triclinic crystal form”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #26065 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1WDX
Type: protein
Length: 252 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Myosin tail region-interacting protein MTI1
UniProt: P47068
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 49% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Myosin tail region-interacting protein MTI1	protein	63	5% helix, 49% strand	P47068

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	201	0.52	0.77	32	empty
2	77	0.35	0.76	20	empty

Interfaces

4 interfaces between chains.

A–D · 544 Å² buried · 1 hydrogen bond · protein-protein
B–C · 538 Å² buried · 0 hydrogen bonds · protein-protein
A–B · 269 Å² buried · 2 hydrogen bonds · protein-protein
B–D · 254 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

1WDX · Yeast BBC1 SH3 domain, triclinic crystal form · the same entry in another collection · chain D against D, TM-score 1.00
P47068 · AlphaFold monomer V2.0 prediction for myosin tail region-interacting protein MTI1 (P47068) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P47068
Elsewhere: RCSB PDB 1WDX · PDBe 1WDX · UniProt P47068

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