MolNFT v1 · #26031 · protein

Crystal structure of uroporphyrinogen III synthase from an extremely thermophilic bacterium thermus thermophilus HB8 (wild type, native, form-1 crystal)

1WCW: “Crystal structure of uroporphyrinogen III synthase from an extremely thermophilic bacterium thermus…”. X-ray diffraction, 1 pocket (best druggability 0.69). MolNFT v1 #26031 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1WCW
Type: protein
Length: 254 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uroporphyrinogen III synthase
EC: 4.2.1.75
UniProt: Q5SKH2
Pockets: 1 · best druggability 0.69

Structure

x-ray diffraction · 1 distinct chain · 49% helix, 20% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Uroporphyrinogen III synthase (EC 4.2.1.75)	protein	254	49% helix, 20% strand	Q5SKH2

Ligands and binding sites

GOL · Glycerol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	633	0.69	0.78	51	GOL

Compared structures

1WCW · Crystal Structure of Uroporphyrinogen III Synthase from an Extremely Thermophilic… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q5SKH2
Elsewhere: RCSB PDB 1WCW · PDBe 1WCW · UniProt Q5SKH2

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