MolNFT v1 · #26027 · protein
A mutant of trypanosoma rangeli sialidase displaying trans- sialidase activity
1WCS: “A mutant of trypanosoma rangeli sialidase displaying trans- sialidase activity”. X-ray diffraction, 4 pockets (best druggability 0.62). MolNFT v1 #26027 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WCS
- Type
- protein
- Length
- 628 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Sialidase
- EC
- 3.2.1.18
- UniProt
- O44049
- Pockets
- 4 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 6% helix, 45% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Sialidase (EC 3.2.1.18) | protein | 628 | 6% helix, 45% strand | O44049 |
Pockets
4 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 312 | 0.62 | 0.79 | 34 | empty |
| 2 | 247 | 0.55 | 0.77 | 31 | empty |
| 3 | 133 | 0.49 | 0.79 | 23 | empty |
| 4 | 50 | 0.24 | 0.73 | 18 | empty |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1WCS · A mutant of Trypanosoma rangeli sialidase displaying trans-sialidase activity · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O44049
- Elsewhere: RCSB PDB 1WCS · PDBe 1WCS · UniProt O44049
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