MolNFT v1 · #25947 · protein
Back-priming mode of PHI6 RNA-dependent RNA polymerase
1WAC · P2 protein: “Back-priming mode of PHI6 RNA-dependent RNA polymerase”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #25947 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1WAC
- Type
- protein
- Length
- 1,986 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- P2 protein
- UniProt
- P11124
- Pockets
- 20 · best druggability 0.80
Structure
x-ray diffraction · 1 distinct chain · 45% helix, 14% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C | P2 protein | protein | 662 | 45% helix, 14% strand | P11124 |
Pockets
20 pockets found on a 1 Å grid, 14 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 850 | 0.80 | 0.82 | 82 | empty |
| 2 | 861 | 0.79 | 0.82 | 80 | empty |
| 3 | 891 | 0.78 | 0.81 | 82 | empty |
| 4 | 608 | 0.77 | 0.83 | 73 | empty |
| 5 | 944 | 0.77 | 0.79 | 80 | empty |
Interfaces
2 interfaces between chains.
- B–C · 506 Ų buried · 4 hydrogen bonds · protein-protein
- A–C · 476 Ų buried · 5 hydrogen bonds · protein-protein
Compared structures
- 1WAC · Back-priming mode of Phi6 RNA-dependent RNA polymerase · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P11124
- Elsewhere: RCSB PDB 1WAC · PDBe 1WAC · UniProt P11124
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