MolNFT v1 · #25909 · protein
Crystal structure of RV1155 from mycobacterium tuberculosis
1W9A · Putative PYRIDOXINE/PYRIDOXAMINE 5'-phosphate oxidase: “Crystal structure of RV1155 from mycobacterium tuberculosis”. X-ray diffraction, 3 pockets (best druggability 0.58). MolNFT v1 #25909 on GenesisL1: 3D structure, binding sites…
- PDB
- 1W9A
- Type
- protein
- Length
- 285 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Putative PYRIDOXINE/PYRIDOXAMINE 5'-phosphate oxidase
- EC
- 1.4.3.5
- UniProt
- O06553
- Pockets
- 3 · best druggability 0.58
Structure
x-ray diffraction · 2 distinct chains · 28% helix, 36% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Putative PYRIDOXINE/PYRIDOXAMINE 5'-phosphate oxidase (EC 1.4.3.5) | protein | 142 | 27% helix, 37% strand | O06553 |
| B | Putative PYRIDOXINE/PYRIDOXAMINE 5'-phosphate oxidase (EC 1.4.3.5) | protein | 143 | 29% helix, 36% strand | O06553 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.58 | 0.77 | 35 | empty |
| 2 | 180 | 0.48 | 0.76 | 27 | empty |
| 3 | 82 | 0.47 | 0.82 | 22 | empty |
Interfaces
1 interface between chains.
- A–B · 1294 Ų buried · 15 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 modified (engineered).
Compared structures
- 1W9A · Crystal structure of Rv1155 from Mycobacterium tuberculosis · the same entry in another collection · chain A against A, TM-score 1.00
- O06553 · AlphaFold monomer V2.0 prediction for F420H(2)-dependent reductase RV1155 (O06553) · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O06553
- Elsewhere: RCSB PDB 1W9A · PDBe 1W9A · UniProt O06553
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.