MolNFT v1 · #25904 · protein
Crystal structure of mil (MTH680), an archaeal IMP4-like protein
1W94 · Probable brix-domain ribosomal biogenesis protein: “Crystal structure of mil (MTH680), an archaeal IMP4-like protein”. X-ray diffraction, 2 pockets (best druggability 0.66). MolNFT v1 #25904 on GenesisL1: 3D structure, binding sites…
- PDB
- 1W94
- Type
- protein
- Length
- 304 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Probable brix-domain ribosomal biogenesis protein
- UniProt
- O26776
- Pockets
- 2 · best druggability 0.66
Structure
x-ray diffraction · 2 distinct chains · 19% helix, 39% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Probable brix-domain ribosomal biogenesis protein | protein | 155 | 19% helix, 39% strand | O26776 |
| B | Probable brix-domain ribosomal biogenesis protein | protein | 149 | 19% helix, 40% strand | O26776 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.66 | 0.96 | 22 | empty |
| 2 | 237 | 0.49 | 0.75 | 35 | empty |
Interfaces
1 interface between chains.
- A–B · 800 Ų buried · 14 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 14 modified, 2 disulfide (engineered, disulfide).
Compared structures
- 1W94 · Crystal Structure of Mil (Mth680), an archaeal Imp4-like protein · the same entry in another collection · chain A against A, TM-score 1.00
- O26776 · AlphaFold monomer V2.0 prediction for probable brix domain-containing ribosomal… · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O26776
- Elsewhere: RCSB PDB 1W94 · PDBe 1W94 · UniProt O26776
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