MolNFT v1 · #2590 · protein
A1C12 subcomplex of F1FO ATP synthase
1C17 · ATP synthase subunit C: “A1C12 subcomplex of F1FO ATP synthase”. Solution nmr, 20 pockets (best druggability 0.86). MolNFT v1 #2590 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1C17
- Type
- protein
- Length
- 1,090 residues
- Chains
- 13
- Method
- solution nmr
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- ATP synthase subunit C; ATP synthase subunit a
- UniProt
- P68699, P0AB98
- Pockets
- 20 · best druggability 0.86
Structure
solution nmr · 2 distinct chains · 84% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D, E, F, G, H, I, J, K, L | ATP synthase subunit C | protein | 79 | 85% helix, 0% strand | P68699 |
| M | ATP synthase subunit a | protein | 142 | 84% helix, 0% strand | P0AB98 |
Pockets
20 pockets found on a 1 Å grid, 18 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1150 | 0.86 | 0.86 | 129 | empty |
| 2 | 564 | 0.71 | 0.79 | 57 | empty |
| 3 | 264 | 0.68 | 0.83 | 34 | empty |
| 4 | 70 | 0.58 | 0.88 | 26 | empty |
| 5 | 103 | 0.57 | 0.85 | 21 | empty |
Interfaces
14 interfaces between chains.
- E–F · 1232 Ų buried · 1 hydrogen bond · protein-protein
- C–D · 1222 Ų buried · 1 hydrogen bond · protein-protein
- D–E · 1214 Ų buried · 1 hydrogen bond · protein-protein
- J–K · 1198 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 1193 Ų buried · 1 hydrogen bond · protein-protein
Compared structures
- 1C17 · A1C12 subcomplex of F1FO ATP synthase · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P68699
- Every structure of UniProt P0AB98
- Elsewhere: RCSB PDB 1C17 · PDBe 1C17 · UniProt P68699 · UniProt P0AB98
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