MolNFT v1 · #25851 · protein
Crystal structure of human kynurenine aminotransferase I
1W7L · Kynurenine--oxoglutarate transaminase I: “Crystal structure of human kynurenine aminotransferase I”. X-ray diffraction, 1 ligand (PLP), 4 pockets (best druggability 0.63). MolNFT v1 #25851 on GenesisL1: 3D structure, binding sites…
- PDB
- 1W7L
- Type
- protein
- Length
- 415 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Kynurenine--oxoglutarate transaminase I
- EC
- 4.4.1.13
- UniProt
- Q16773
- Ligands
- PLP
- Pockets
- 4 · best druggability 0.63
Structure
x-ray diffraction · 1 distinct chain · 47% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Kynurenine--oxoglutarate transaminase I (EC 4.4.1.13) | protein | 415 | 47% helix, 16% strand | Q16773 |
Ligands and binding sites
- PLP · Pyridoxal-5'-phosphate · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 237 | 0.63 | 0.81 | 39 | PLP |
| 2 | 191 | 0.49 | 0.76 | 21 | empty |
| 3 | 142 | 0.45 | 0.76 | 21 | empty |
| 4 | 50 | 0.27 | 0.74 | 14 | empty |
Modifications
Observed in the structure: 1 cofactor (pyridoxal phosphate Schiff base).
Compared structures
- 1W7L · Crystal structure of human kynurenine aminotransferase I · the same entry in another collection · chain A against A, TM-score 1.00
- Q16773 · AlphaFold monomer V2.0 prediction for kynurenine--oxoglutarate transaminase 1 (Q16773) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q16773
- Elsewhere: RCSB PDB 1W7L · PDBe 1W7L · UniProt Q16773
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.