MolNFT v1 · #25850 · protein
E.COLI folc in complex with ADP, without folate substrate
1W7K · Folc bifunctional protein: “E.COLI folc in complex with ADP, without folate substrate”. X-ray diffraction, 3 ligands (ADP, MG, SO4), 2 pockets (best druggability 0.74). MolNFT v1 #25850 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1W7K
- Type
- protein
- Length
- 411 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Folc bifunctional protein
- EC
- 6.3.2.12
- UniProt
- P08192
- Ligands
- ADP, MG, SO4
- Pockets
- 2 · best druggability 0.74
Structure
x-ray diffraction · 1 distinct chain · 43% helix, 18% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Folc bifunctional protein (EC 6.3.2.12) | protein | 411 | 43% helix, 18% strand | P08192 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · chains A
- MG · Magnesium ion · metal · 2 copies · chains A
- SO4 · Sulfate ion · ion · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 738 | 0.74 | 0.79 | 76 | ADP, SO4, MG |
| 2 | 87 | 0.49 | 0.83 | 20 | empty |
Modifications
Observed in the structure: 1 modified (carboxylation).
Compared structures
- 1W7K · E.coli FolC in complex with ADP, without folate substrate · the same entry in another collection · chain A against A, TM-score 1.00
- P08192 · AlphaFold monomer V2.0 prediction for dihydrofolate SYNTHASE/FOLYLPOLYGLUTAMATE synthase… · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08192
- Elsewhere: RCSB PDB 1W7K · PDBe 1W7K · UniProt P08192
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