MolNFT v1 · #25735 · protein

The 2.5 angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus.

1W45: “The 2.5 angstroem structure of the K16A mutant of annexin A8, which has an intact N-terminus.”. X-ray diffraction, 6 pockets (best druggability 0.62). MolNFT v1 #25735 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1W45
Type: protein
Length: 640 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Annexin A8
UniProt: P13928
Pockets: 6 · best druggability 0.62

Structure

x-ray diffraction · 1 distinct chain · 72% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Annexin A8	protein	320	72% helix, 0% strand	P13928

Pockets

6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	298	0.62	0.79	30	empty
2	90	0.43	0.79	17	empty
3	74	0.41	0.79	17	empty
4	81	0.32	0.74	15	empty
5	50	0.32	0.78	13	empty

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

1W45 · The 2.5 Angstroem structure of the K16A mutant of annexin A8, which has an intact… · the same entry in another collection · chain A against A, TM-score 1.00
P13928 · AlphaFold monomer V2.0 prediction for annexin A8 (P13928) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P13928
Elsewhere: RCSB PDB 1W45 · PDBe 1W45 · UniProt P13928

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