MolNFT v1 · #25610 · protein
Crystallographic structure of the nuclease domain of 3'HEXO, a deddh family member, bound to ramp
1W0H · 3'-5' exonuclease ERI1: “Crystallographic structure of the nuclease domain of 3'HEXO, a deddh family member, bound to ramp”. X-ray diffraction, 2 ligands (AMP, MG), 1 pocket (best druggability 0.47). MolNFT v1 #25610 on GenesisL1…
- PDB
- 1W0H
- Type
- protein
- Length
- 200 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- 3'-5' exonuclease ERI1
- EC
- 3.1.-.-
- UniProt
- Q8IV48
- Ligands
- AMP, MG
- Pockets
- 1 · best druggability 0.47
Structure
x-ray diffraction · 1 distinct chain · 40% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | 3'-5' exonuclease ERI1 (EC 3.1.-.-) | protein | 200 | 40% helix, 20% strand | Q8IV48 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 196 | 0.47 | 0.75 | 26 | AMP |
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1W0H · Crystallographic structure of the nuclease domain of 3'hExo, a DEDDh family member, bound… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8IV48 · AlphaFold monomer V2.0 prediction for 3'-5' exoribonuclease 1 (Q8IV48) · a predicted model of the same protein · chain A against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8IV48
- Elsewhere: RCSB PDB 1W0H · PDBe 1W0H · UniProt Q8IV48
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