MolNFT v1 · #25593 · protein

Crystal structure of mutant enzyme D103L of ketosteroid isomerase from pseudomonas putida biotype B

1W00 · Steroid delta-isomerase: “Crystal structure of mutant enzyme D103L of ketosteroid isomerase from pseudomonas putida biotype B”. X-ray diffraction, 3 pockets (best druggability 0.63). MolNFT v1 #25593 on GenesisL1: 3D structure…

PDB: 1W00
Type: protein
Length: 247 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Steroid delta-isomerase
EC: 5.3.3.1
UniProt: P07445
Pockets: 3 · best druggability 0.63

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 40% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Steroid delta-isomerase (EC 5.3.3.1)	protein	124	31% helix, 40% strand	P07445
B	Steroid delta-isomerase (EC 5.3.3.1)	protein	123	32% helix, 41% strand	P07445

Pockets

3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	217	0.63	0.82	25	empty
2	216	0.62	0.81	24	empty
3	85	0.38	0.77	17	empty

Interfaces

1 interface between chains.

A–B · 1082 Å² buried · 18 hydrogen bonds · protein-protein

Compared structures

1W00 · Crystal structure of mutant enzyme D103L of Ketosteroid Isomerase from Pseudomonas putida… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P07445
Elsewhere: RCSB PDB 1W00 · PDBe 1W00 · UniProt P07445

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