MolNFT v1 · #25560 · protein
BETA4 subunit of CA2+ channel
1VYV · Calcium channel beta-4SUBUNIT: “BETA4 subunit of CA2+ channel”. X-ray diffraction, 6 pockets (best druggability 0.55). MolNFT v1 #25560 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1VYV
- Type
- protein
- Length
- 549 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium channel beta-4SUBUNIT
- Pockets
- 6 · best druggability 0.55
Structure
x-ray diffraction · 2 distinct chains · 40% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium channel beta-4SUBUNIT | protein | 274 | 41% helix, 20% strand | — |
| B | Calcium channel beta-4SUBUNIT | protein | 275 | 39% helix, 19% strand | — |
Pockets
6 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 377 | 0.55 | 0.74 | 37 | empty |
| 2 | 100 | 0.46 | 0.80 | 21 | empty |
| 3 | 121 | 0.43 | 0.77 | 24 | empty |
| 4 | 104 | 0.38 | 0.75 | 18 | empty |
| 5 | 92 | 0.37 | 0.75 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 247 Ų buried · 5 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 modified (engineered).
Compared structures
- 1VYV · beta4 subunit of Ca2+ channel · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1VYV · PDBe 1VYV
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.