MolNFT v1 · #25558 · protein
BETA3 subunit complexed with aid
1VYT · Calcium channel beta-3 subunit: “BETA3 subunit complexed with aid”. X-ray diffraction, 8 pockets (best druggability 0.76). MolNFT v1 #25558 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1VYT
- Type
- protein
- Length
- 608 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Calcium channel beta-3 subunit; Voltage-dependent L-type calcium channel alpha-1C subunit
- UniProt
- P54287, P22002
- Pockets
- 8 · best druggability 0.76
Structure
x-ray diffraction · 4 distinct chains · 44% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Calcium channel beta-3 subunit | protein | 273 | 42% helix, 20% strand | P54287 |
| B | Calcium channel beta-3 subunit | protein | 294 | 41% helix, 20% strand | P54287 |
| E | Voltage-dependent L-type calcium channel alpha-1C subunit | protein | 25 | 84% helix, 0% strand | P22002 |
| F | Voltage-dependent L-type calcium channel alpha-1C subunit | protein | 16 | 81% helix, 0% strand | P22002 |
Pockets
8 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1044 | 0.76 | 0.78 | 71 | empty |
| 2 | 119 | 0.37 | 0.73 | 22 | empty |
| 3 | 90 | 0.36 | 0.76 | 19 | empty |
| 4 | 66 | 0.36 | 0.77 | 20 | empty |
| 5 | 95 | 0.35 | 0.75 | 16 | empty |
Interfaces
3 interfaces between chains.
- A–E · 834 Ų buried · 8 hydrogen bonds · protein-protein
- B–F · 783 Ų buried · 5 hydrogen bonds · protein-protein
- A–B · 647 Ų buried · 7 hydrogen bonds · protein-protein
Compared structures
- 1VYT · beta3 subunit complexed with aid · the same entry in another collection · chain F against F, TM-score 1.00
- P54287 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
- P22002 · AlphaFold monomer V2.0 prediction for voltage-dependent L-type calcium channel subunit… · a predicted model of the same protein · chain E against A, TM-score 0.78
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P54287
- Every structure of UniProt P22002
- Elsewhere: RCSB PDB 1VYT · PDBe 1VYT · UniProt P54287 · UniProt P22002
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