MolNFT v1 · #25477 · protein
Crystal structure of apo-glyceraldehyde 3-phosphate dehydrogenase from cryptosporidium parvum
1VSU · Glyceraldehyde-3-phosphate dehydrogenase: “Crystal structure of apo-glyceraldehyde 3-phosphate dehydrogenase from cryptosporidium parvum”. X-ray diffraction, 11 pockets (best druggability 0.65). MolNFT v1 #25477 on GenesisL1: 3D…
- PDB
- 1VSU
- Type
- protein
- Length
- 1,300 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Glyceraldehyde-3-phosphate dehydrogenase
- EC
- 1.2.1.12
- UniProt
- Q7YYQ9
- Pockets
- 11 · best druggability 0.65
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Glyceraldehyde-3-phosphate dehydrogenase (EC 1.2.1.12) | protein | 325 | 33% helix, 27% strand | Q7YYQ9 |
Pockets
11 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 456 | 0.65 | 0.78 | 49 | empty |
| 2 | 411 | 0.65 | 0.78 | 52 | empty |
| 3 | 311 | 0.63 | 0.80 | 50 | empty |
| 4 | 227 | 0.48 | 0.75 | 38 | empty |
| 5 | 195 | 0.46 | 0.75 | 33 | empty |
Interfaces
6 interfaces between chains.
- C–D · 2031 Ų buried · 30 hydrogen bonds · protein-protein
- A–B · 2009 Ų buried · 33 hydrogen bonds · protein-protein
- A–D · 758 Ų buried · 10 hydrogen bonds · protein-protein
- B–C · 747 Ų buried · 10 hydrogen bonds · protein-protein
- A–C · 519 Ų buried · 6 hydrogen bonds · protein-protein
Compared structures
- 1VSU · Crystal Structure of Apo-glyceraldehyde 3-phosphate dehydrogenase from Cryptosporidium… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7YYQ9
- Elsewhere: RCSB PDB 1VSU · PDBe 1VSU · UniProt Q7YYQ9
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