MolNFT v1 · #25461 · protein

VCAM-1

1VSC · Vascular cell adhesion molecule-1: “VCAM-1”. X-ray diffraction, 6 pockets (best druggability 0.59). MolNFT v1 #25461 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VSC
Type: protein
Length: 392 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Vascular cell adhesion molecule-1
UniProt: P19320
Pockets: 6 · best druggability 0.59

Structure

x-ray diffraction · 1 distinct chain · 5% helix, 54% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Vascular cell adhesion molecule-1	protein	196	5% helix, 54% strand	P19320

Pockets

6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	169	0.59	0.82	28	empty
2	334	0.57	0.76	39	empty
3	248	0.50	0.75	38	empty
4	90	0.38	0.77	23	empty
5	81	0.35	0.76	14	empty

Interfaces

1 interface between chains.

A–B · 813 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide (disulfide).

Compared structures

1VSC · VCAM-1 · the same entry in another collection · chain A against A, TM-score 1.00
P19320 · AlphaFold monomer V2.0 prediction for vascular cell adhesion protein 1 (P19320) · a predicted model of the same protein · chain A against A, TM-score 0.89

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P19320
Elsewhere: RCSB PDB 1VSC · PDBe 1VSC · UniProt P19320

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