MolNFT v1 · #25416 · protein
Crystal structure of anthranilate phosphoribosyltransferase 2 (17130499) from nostoc sp. at 1.85 a resolution
1VQU: “Crystal structure of anthranilate phosphoribosyltransferase 2 (17130499) from nostoc sp. at 1.85 a resolution”. X-ray diffraction, 7 pockets (best druggability 0.72). MolNFT v1 #25416 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1VQU
- Type
- protein
- Length
- 664 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Anthranilate phosphoribosyltransferase 2
- EC
- 2.4.2.18
- UniProt
- Q8YXQ9
- Pockets
- 7 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 51% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Anthranilate phosphoribosyltransferase 2 (EC 2.4.2.18) | protein | 334 | 52% helix, 14% strand | Q8YXQ9 |
| B | Anthranilate phosphoribosyltransferase 2 (EC 2.4.2.18) | protein | 330 | 51% helix, 13% strand | Q8YXQ9 |
Ligands and binding sites
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
7 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 589 | 0.72 | 0.80 | 55 | GOL |
| 2 | 403 | 0.71 | 0.82 | 56 | ACT |
| 3 | 130 | 0.55 | 0.82 | 24 | empty |
| 4 | 173 | 0.53 | 0.79 | 20 | empty |
| 5 | 134 | 0.52 | 0.80 | 27 | empty |
Interfaces
1 interface between chains.
- A–B · 947 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 modified (engineered).
Compared structures
- 1VQU · Crystal structure of Anthranilate phosphoribosyltransferase 2 (17130499) from Nostoc sp.… · the same entry in another collection · chain A against A, TM-score 1.00
- Q8YXQ9 · AlphaFold monomer V2.0 prediction for anthranilate phosphoribosyltransferase 2 (Q8YXQ9) · a predicted model of the same protein · chain B against A, TM-score 0.98
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8YXQ9
- Elsewhere: RCSB PDB 1VQU · PDBe 1VQU · UniProt Q8YXQ9
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