MolNFT v1 · #25206 · protein
Crystal structure of pseudouridylate synthase
1VIO · Ribosomal small subunit pseudouridine synthase a: “Crystal structure of pseudouridylate synthase”. X-ray diffraction, 2 pockets (best druggability 0.86). MolNFT v1 #25206 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1VIO
- Type
- protein
- Length
- 460 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Ribosomal small subunit pseudouridine synthase a
- EC
- 4.2.1.70
- UniProt
- P45124
- Pockets
- 2 · best druggability 0.86
Structure
x-ray diffraction · 1 distinct chain · 24% helix, 27% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Ribosomal small subunit pseudouridine synthase a (EC 4.2.1.70) | protein | 230 | 24% helix, 27% strand | P45124 |
Ligands and binding sites
- BU1 · 1,4-butanediol · additive · 4 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1089 | 0.86 | 0.87 | 121 | BU1 |
| 2 | 57 | 0.30 | 0.75 | 12 | empty |
Interfaces
1 interface between chains.
- A–B · 1241 Ų buried · 10 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P45124
- Elsewhere: RCSB PDB 1VIO · PDBe 1VIO · UniProt P45124
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