MolNFT v1 · #25184 · protein

Crystal structure of a fatty ACID/PHOSPHOLIPID synthesis protein

1VI1 · Fatty ACID/PHOSPHOLIPID synthesis protein plsx: “Crystal structure of a fatty ACID/PHOSPHOLIPID synthesis protein”. X-ray diffraction, 5 pockets (best druggability 0.60). MolNFT v1 #25184 on GenesisL1: 3D structure, binding sites…

PDB: 1VI1
Type: protein
Length: 648 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Fatty ACID/PHOSPHOLIPID synthesis protein plsx
UniProt: P71018
Pockets: 5 · best druggability 0.60

Structure

x-ray diffraction · 2 distinct chains · 45% helix, 18% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Fatty ACID/PHOSPHOLIPID synthesis protein plsx	protein	327	46% helix, 18% strand	P71018
B	Fatty ACID/PHOSPHOLIPID synthesis protein plsx	protein	321	44% helix, 18% strand	P71018

Pockets

5 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	200	0.60	0.81	30	empty
2	71	0.53	0.86	19	empty
3	113	0.43	0.77	21	empty
4	60	0.36	0.78	15	empty
5	63	0.30	0.74	13	empty

Modifications

Observed in the structure: 24 modified (engineered).

Compared structures

1VI1 · Crystal structure of a fatty acid/phospholipid synthesis protein · the same entry in another collection · chain A against A, TM-score 1.00
P71018 · AlphaFold monomer V2.0 prediction for phosphate acyltransferase (P71018) · a predicted model of the same protein · chain B against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P71018
Elsewhere: RCSB PDB 1VI1 · PDBe 1VI1 · UniProt P71018

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