MolNFT v1 · #25118 · protein

Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga maritima F132A/L128A mutant

1VG4 · Octoprenyl-diphosphate synthase: “Crystal structure of octaprenyl pyrophosphate synthase from hyperthermophilic thermotoga maritima F132A/L128A…”. X-ray diffraction, 10 pockets (best druggability 0.78). MolNFT v1 #25118 on…

PDB: 1VG4
Type: protein
Length: 560 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Octoprenyl-diphosphate synthase
EC: 2.5.1.11
UniProt: Q9X1M1
Pockets: 10 · best druggability 0.78

Structure

x-ray diffraction · 1 distinct chain · 73% helix, 1% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Octoprenyl-diphosphate synthase (EC 2.5.1.11)	protein	280	73% helix, 1% strand	Q9X1M1

Pockets

10 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	114	0.78	0.96	29	empty
2	345	0.77	0.87	49	empty
3	614	0.74	0.81	55	empty
4	65	0.73	0.98	25	empty
5	278	0.58	0.77	26	empty

Interfaces

1 interface between chains.

A–B · 1670 Å² buried · 14 hydrogen bonds · protein-protein

Compared structures

1VG4 · Crystal Structure Of Octaprenyl Pyrophosphate Synthase From Hyperthermophilic Thermotoga… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q9X1M1
Elsewhere: RCSB PDB 1VG4 · PDBe 1VG4 · UniProt Q9X1M1

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