MolNFT v1 · #25098 · protein

Crystal structure of TT1020 from thermus thermophilus HB8

1VFJ · Nitrogen regulatory protein P-II: “Crystal structure of TT1020 from thermus thermophilus HB8”. X-ray diffraction, 3 pockets (best druggability 0.71). MolNFT v1 #25098 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VFJ
Type: protein
Length: 300 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nitrogen regulatory protein P-II
UniProt: P83820
Pockets: 3 · best druggability 0.71

Structure

x-ray diffraction · 3 distinct chains · 31% helix, 37% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Nitrogen regulatory protein P-II	protein	116	31% helix, 31% strand	P83820
B	Nitrogen regulatory protein P-II	protein	93	31% helix, 40% strand	P83820
C	Nitrogen regulatory protein P-II	protein	91	31% helix, 41% strand	P83820

Pockets

3 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	207	0.71	0.87	36	empty
2	95	0.67	0.91	26	empty
3	224	0.59	0.80	30	empty

Interfaces

3 interfaces between chains.

A–B · 1401 Å² buried · 21 hydrogen bonds · protein-protein
B–C · 1172 Å² buried · 21 hydrogen bonds · protein-protein
A–C · 1117 Å² buried · 15 hydrogen bonds · protein-protein

Compared structures

1VFJ · Crystal structure of TT1020 from Thermus thermophilus HB8 · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83820
Elsewhere: RCSB PDB 1VFJ · PDBe 1VFJ · UniProt P83820

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