MolNFT v1 · #25085 · protein

2.1 ångström crystal structure of the pals-1-L27N and patj L27 heterodimer complex

1VF6 · PALS1-associated tight junction protein: “2.1 ångström crystal structure of the pals-1-L27N and patj L27 heterodimer complex”. X-ray diffraction, 1 pocket (best druggability 0.35). MolNFT v1 #25085 on GenesisL1: 3D structure…

PDB: 1VF6
Type: protein
Length: 217 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: PALS1-associated tight junction protein; Maguk P55 subfamily member 5
UniProt: Q8NI35, Q9JLB2
Pockets: 1 · best druggability 0.35

Structure

x-ray diffraction · 4 distinct chains · 84% helix, 0% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	PALS1-associated tight junction protein	protein	58	84% helix, 0% strand	Q8NI35
B	PALS1-associated tight junction protein	protein	60	83% helix, 0% strand	Q8NI35
C	Maguk P55 subfamily member 5	protein	51	82% helix, 0% strand	Q9JLB2
D	Maguk P55 subfamily member 5	protein	48	88% helix, 0% strand	Q9JLB2

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	56	0.35	0.78	9	empty

Interfaces

5 interfaces between chains.

B–D · 1110 Å² buried · 11 hydrogen bonds · protein-protein
A–C · 1088 Å² buried · 11 hydrogen bonds · protein-protein
A–B · 628 Å² buried · 0 hydrogen bonds · protein-protein
B–C · 107 Å² buried · 0 hydrogen bonds · protein-protein
A–D · 96 Å² buried · 0 hydrogen bonds · protein-protein

Compared structures

1VF6 · 2.1 Angstrom crystal structure of the PALS-1-L27N and PATJ L27 heterodimer complex · the same entry in another collection · chain D against D, TM-score 1.00
Q9JLB2 · AlphaFold monomer V2.0 prediction for maguk P55 subfamily member 5 (Q9JLB2) · a predicted model of the same protein · chain D against A, TM-score 0.97
Q8NI35 · AlphaFold monomer V2.0 prediction for inad-like protein (Q8NI35) · a predicted model of the same protein · chain A against A, TM-score 0.80

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q8NI35
Every structure of UniProt Q9JLB2
Elsewhere: RCSB PDB 1VF6 · PDBe 1VF6 · UniProt Q8NI35 · UniProt Q9JLB2

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