MolNFT v1 · #25076 · protein

Manganese superoxide dismutase from escherichia COLI

1VEW: “Manganese superoxide dismutase from escherichia COLI”. X-ray diffraction, 2 ligands (MN, OH), 8 pockets (best druggability 0.66). MolNFT v1 #25076 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VEW
Type: protein
Length: 820 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Manganese superoxide dismutase
EC: 1.15.1.1
UniProt: P00448
Ligands: MN, OH
Pockets: 8 · best druggability 0.66

Structure

x-ray diffraction · 1 distinct chain · 55% helix, 12% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D	Manganese superoxide dismutase (EC 1.15.1.1)	protein	205	55% helix, 12% strand	P00448

Ligands and binding sites

MN · Manganese (II) ion · metal · 4 copies · chains A, B, C, D
OH · Hydroxide ion · ion · 4 copies · chains A, B, C, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

8 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	598	0.66	0.76	78	empty
2	178	0.54	0.79	23	empty
3	162	0.54	0.80	22	empty
4	182	0.52	0.78	25	empty
5	168	0.52	0.79	19	empty

Interfaces

3 interfaces between chains.

A–B · 919 Å² buried · 13 hydrogen bonds · protein-protein
C–D · 914 Å² buried · 13 hydrogen bonds · protein-protein
A–D · 214 Å² buried · 5 hydrogen bonds · protein-protein

Compared structures

1VEW · Manganese superoxide dismutase from escherichia COLI · the same entry in another collection · chain A against A, TM-score 1.00
P00448 · AlphaFold monomer V2.0 prediction for superoxide dismutase [mn] (P00448) · a predicted model of the same protein · chain A against A, TM-score 0.99

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P00448
Elsewhere: RCSB PDB 1VEW · PDBe 1VEW · UniProt P00448

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.