MolNFT v1 · #25073 · protein
Crystal structure of P14/MP1 at 1.9 a resolution
1VET · Mitogen-activated protein kinase kinase 1 interacting…: “Crystal structure of P14/MP1 at 1.9 a resolution”. X-ray diffraction, 1 pocket (best druggability 0.28). MolNFT v1 #25073 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 1VET
- Type
- protein
- Length
- 240 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Mitogen-activated protein kinase kinase 1 interacting protein 1; Late ENDOSOMAL/LYSOSOMAL…
- UniProt
- O88653, Q9JHS3
- Pockets
- 1 · best druggability 0.28
Structure
x-ray diffraction · 2 distinct chains · 38% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Mitogen-activated protein kinase kinase 1 interacting protein 1 | protein | 122 | 38% helix, 30% strand | O88653 |
| B | Late ENDOSOMAL/LYSOSOMAL MP1 interacting protein | protein | 118 | 39% helix, 29% strand | Q9JHS3 |
Pockets
1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 54 | 0.28 | 0.74 | 14 | empty |
Interfaces
1 interface between chains.
- A–B · 1298 Ų buried · 19 hydrogen bonds · protein-protein
Compared structures
- 1VET · Crystal Structure of p14/MP1 at 1.9 A resolution · the same entry in another collection · chain A against A, TM-score 1.00
- O88653 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR3 (O88653) · a predicted model of the same protein · chain A against A, TM-score 0.97
- Q9JHS3 · AlphaFold monomer V2.0 prediction for ragulator complex protein LAMTOR2 (Q9JHS3) · a predicted model of the same protein · chain B against A, TM-score 0.93
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O88653
- Every structure of UniProt Q9JHS3
- Elsewhere: RCSB PDB 1VET · PDBe 1VET · UniProt O88653 · UniProt Q9JHS3
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