MolNFT v1 · #25054 · protein
Crystal structure of hutp, an RNA binding antitermination protein
1VEA · Hut operon positive regulatory protein: “Crystal structure of hutp, an RNA binding antitermination protein”. X-ray diffraction, 1 ligand (HBN), 3 pockets (best druggability 0.53). MolNFT v1 #25054 on GenesisL1: 3D structure, binding…
- PDB
- 1VEA
- Type
- protein
- Length
- 287 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Hut operon positive regulatory protein
- UniProt
- P10943
- Ligands
- HBN
- Pockets
- 3 · best druggability 0.53
Structure
x-ray diffraction · 2 distinct chains · 39% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Hut operon positive regulatory protein | protein | 143 | 39% helix, 26% strand | P10943 |
| B | Hut operon positive regulatory protein | protein | 144 | 38% helix, 26% strand | P10943 |
Ligands and binding sites
- HBN · N-(2-naphthyl)histidinamide · ligand · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 91 | 0.53 | 0.84 | 17 | empty |
| 2 | 85 | 0.44 | 0.80 | 24 | HBN |
| 3 | 61 | 0.38 | 0.79 | 16 | empty |
Interfaces
1 interface between chains.
- A–B · 1050 Ų buried · 14 hydrogen bonds · protein-protein
Compared structures
- 1VEA · Crystal Structure of HutP, an RNA binding antitermination protein · the same entry in another collection · chain A against A, TM-score 1.00
- P10943 · AlphaFold monomer V2.0 prediction for hut operon positive regulatory protein (P10943) · a predicted model of the same protein · chain A against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P10943
- Elsewhere: RCSB PDB 1VEA · PDBe 1VEA · UniProt P10943
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