MolNFT v1 · #25026 · protein
Crystal structure of LIR1.01, one of the alleles of LIR1
1VDG · Leukocyte immunoglobulin-like receptor subfamily B member 1: “Crystal structure of LIR1.01, one of the alleles of LIR1”. X-ray diffraction, 3 pockets (best druggability 0.77). MolNFT v1 #25026 on GenesisL1: 3D structure, binding…
- PDB
- 1VDG
- Type
- protein
- Length
- 374 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Leukocyte immunoglobulin-like receptor subfamily B member 1
- UniProt
- Q8NHL6
- Pockets
- 3 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 6% helix, 42% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Leukocyte immunoglobulin-like receptor subfamily B member 1 | protein | 187 | 6% helix, 42% strand | Q8NHL6 |
| B | Leukocyte immunoglobulin-like receptor subfamily B member 1 | protein | 187 | 6% helix, 42% strand | Q8NHL6 |
Pockets
3 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1106 | 0.77 | 0.79 | 98 | empty |
| 2 | 88 | 0.54 | 0.85 | 17 | empty |
| 3 | 54 | 0.28 | 0.74 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 1598 Ų buried · 22 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 6 disulfide (disulfide).
Compared structures
- 1VDG · Crystal structure of LIR1.01, one of the alleles of LIR1 · the same entry in another collection · chain A against A, TM-score 1.00
- Q8NHL6 · AlphaFold monomer V2.0 prediction for leukocyte immunoglobulin-like receptor subfamily B… · a predicted model of the same protein · chain B against A, TM-score 0.97
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q8NHL6
- Elsewhere: RCSB PDB 1VDG · PDBe 1VDG · UniProt Q8NHL6
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