MolNFT v1 · #2494 · protein

Human plasminogen activator inhibitor-2. loop (66-98) deletion mutant

1BY7 · Protein (plasminogen activator inhibitor-2): “Human plasminogen activator inhibitor-2. loop (66-98) deletion mutant”. X-ray diffraction, 4 pockets (best druggability 0.50). MolNFT v1 #2494 on GenesisL1: 3D structure, binding sites…

PDB: 1BY7
Type: protein
Length: 354 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Protein (plasminogen activator inhibitor-2)
UniProt: P05120
Pockets: 4 · best druggability 0.50

Structure

x-ray diffraction · 1 distinct chain · 31% helix, 33% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Protein (plasminogen activator inhibitor-2)	protein	354	31% helix, 33% strand	P05120

Pockets

4 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	111	0.50	0.81	29	empty
2	68	0.43	0.81	19	empty
3	66	0.31	0.74	15	empty
4	56	0.29	0.75	19	empty

Modifications

Observed in the structure: 1 disulfide (disulfide).

Compared structures

1BY7 · Human plasminogen activator inhibitor-2. loop (66-98) deletion mutant · the same entry in another collection · chain A against A, TM-score 1.00
P05120 · AlphaFold monomer V2.0 prediction for plasminogen activator inhibitor 2 (P05120) · a predicted model of the same protein · chain A against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P05120
Elsewhere: RCSB PDB 1BY7 · PDBe 1BY7 · UniProt P05120

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