MolNFT v1 · #24939 · protein

Crystal structure of uricase from arthrobacter globiformis

1VAX · Uric acid oxidase: “Crystal structure of uricase from arthrobacter globiformis”. X-ray diffraction, 20 pockets (best druggability 0.80). MolNFT v1 #24939 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1VAX
Type: protein
Length: 2,296 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Uric acid oxidase
EC: 1.7.3.3
Pockets: 20 · best druggability 0.80

Structure

x-ray diffraction · 1 distinct chain · 25% helix, 42% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B, C, D, E, F, G, H	Uric acid oxidase (EC 1.7.3.3)	protein	287	25% helix, 42% strand	—

Pockets

20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	1000	0.80	0.81	96	empty
2	975	0.80	0.81	99	empty
3	890	0.77	0.79	83	empty
4	864	0.76	0.79	84	empty
5	968	0.71	0.76	98	empty

Interfaces

15 interfaces between chains.

F–G · 3311 Å² buried · 57 hydrogen bonds · protein-protein
B–C · 3309 Å² buried · 54 hydrogen bonds · protein-protein
E–H · 3279 Å² buried · 55 hydrogen bonds · protein-protein
A–D · 3273 Å² buried · 54 hydrogen bonds · protein-protein
G–H · 2456 Å² buried · 53 hydrogen bonds · protein-protein

Compared structures

1VAX · Crystal Structure of Uricase from Arthrobacter globiformis · the same entry in another collection · chain B against B, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Elsewhere: RCSB PDB 1VAX · PDBe 1VAX

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