MolNFT v1 · #24932 · protein

The monomeric ASP49 secretory phospholipase A2 from the venom of agkistridon piscivorus piscivorus

1VAP: “The monomeric ASP49 secretory phospholipase A2 from the venom of agkistridon piscivorus piscivorus”. X-ray diffraction, 2 pockets (best druggability 0.54). MolNFT v1 #24932 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1VAP
Type: protein
Length: 246 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Phospholipase A2
EC: 3.1.1.4
UniProt: P51972
Pockets: 2 · best druggability 0.54

Structure

x-ray diffraction · 1 distinct chain · 48% helix, 11% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	Phospholipase A2 (EC 3.1.1.4)	protein	123	48% helix, 11% strand	P51972

Pockets

2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	172	0.54	0.79	25	empty
2	132	0.53	0.81	20	empty

Modifications

Observed in the structure: 14 disulfide (disulfide).

Compared structures

1VAP · The monomeric ASP49 secretory phospholipase A2 from the venom of agkistridon piscivorus… · the same entry in another collection · chain A against A, TM-score 1.00
P51972 · AlphaFold monomer V2.0 prediction for basic phospholipase A2 app-D49 (P51972) · a predicted model of the same protein · chain A against A, TM-score 0.97

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P51972
Elsewhere: RCSB PDB 1VAP · PDBe 1VAP · UniProt P51972

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