MolNFT v1 · #24917 · protein
Yeast MYO3 SH3 domain, triclinic crystal form
1VA7 · Myosin-3 isoform: “Yeast MYO3 SH3 domain, triclinic crystal form”. X-ray diffraction, 2 pockets (best druggability 0.38). MolNFT v1 #24917 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1VA7
- Type
- protein
- Length
- 256 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Myosin-3 isoform
- UniProt
- P36006
- Pockets
- 2 · best druggability 0.38
Structure
x-ray diffraction · 2 distinct chains · 5% helix, 44% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Myosin-3 isoform | protein | 68 | 4% helix, 41% strand | P36006 |
| C, D | Myosin-3 isoform | protein | 60 | 5% helix, 47% strand | P36006 |
Ligands and binding sites
- GOL · Glycerol · additive · 2 copies · chains B, C, D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 69 | 0.38 | 0.78 | 13 | empty |
| 2 | 61 | 0.32 | 0.76 | 16 | empty |
Interfaces
4 interfaces between chains.
- A–B · 505 Ų buried · 12 hydrogen bonds · protein-protein
- A–D · 471 Ų buried · 6 hydrogen bonds · protein-protein
- B–C · 470 Ų buried · 7 hydrogen bonds · protein-protein
- B–D · 69 Ų buried · 0 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P36006
- Elsewhere: RCSB PDB 1VA7 · PDBe 1VA7 · UniProt P36006
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