MolNFT v1 · #24810 · protein
Crystal structure of xylanase from streptomyces olivaceoviridis E-86 complexed with 2(2)-4-O-methyl-alpha-D-glucuronosyl-xylobiose
1V6W · Endo-1,4-beta-D-xylanase: “Crystal structure of xylanase from streptomyces olivaceoviridis E-86 complexed with…”. X-ray diffraction, 2 ligands (GCV, XYP), 6 pockets (best druggability 0.66). MolNFT v1 #24810 on GenesisL1: 3D…
- PDB
- 1V6W
- Type
- protein
- Length
- 872 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Endo-1,4-beta-D-xylanase
- EC
- 3.2.1.8
- UniProt
- Q7SI98
- Ligands
- GCV, XYP
- Pockets
- 6 · best druggability 0.66
Structure
x-ray diffraction · 1 distinct chain · 32% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Endo-1,4-beta-D-xylanase (EC 3.2.1.8) | protein | 436 | 32% helix, 25% strand | Q7SI98 |
Ligands and binding sites
- GCV · 4-O-methyl-alpha-D-glucopyranuronic acid · ligand · 2 copies
- XYP · beta-D-xylopyranose · sugar · 8 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
6 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 652 | 0.66 | 0.76 | 72 | empty |
| 2 | 338 | 0.65 | 0.80 | 48 | empty |
| 3 | 479 | 0.63 | 0.76 | 47 | empty |
| 4 | 57 | 0.32 | 0.76 | 15 | empty |
| 5 | 70 | 0.32 | 0.75 | 19 | XYP |
Interfaces
1 interface between chains.
- A–B · 1121 Ų buried · 12 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
- 1V6W · Crystal Structure Of Xylanase From Streptomyces Olivaceoviridis E-86 Complexed With… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q7SI98
- Elsewhere: RCSB PDB 1V6W · PDBe 1V6W · UniProt Q7SI98
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