MolNFT v1 · #24575 · protein

1-pyrroline-5-carboxylate dehydrogenase

1UZB: “1-pyrroline-5-carboxylate dehydrogenase”. X-ray diffraction, 9 pockets (best druggability 0.82). MolNFT v1 #24575 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1UZB
Type: protein
Length: 1,032 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: 1-pyrroline-5-carboxylate dehydrogenase
UniProt: P83849
Pockets: 9 · best druggability 0.82

Structure

x-ray diffraction · 1 distinct chain · 41% helix, 21% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	1-pyrroline-5-carboxylate dehydrogenase	protein	516	41% helix, 21% strand	P83849

Ligands and binding sites

MRD · (4R)-2-methylpentane-2,4-diol · additive · 6 copies · chains A, B

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

9 pockets found on a 1 Å grid, 7 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	688	0.82	0.86	68	empty
2	355	0.72	0.84	60	empty
3	361	0.70	0.82	70	empty
4	454	0.67	0.79	38	MRD
5	505	0.67	0.78	41	empty

Interfaces

1 interface between chains.

A–B · 3153 Å² buried · 54 hydrogen bonds · protein-protein

Compared structures

1UZB · 1-pyrroline-5-carboxylate dehydrogenase · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83849
Elsewhere: RCSB PDB 1UZB · PDBe 1UZB · UniProt P83849

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