MolNFT v1 · #24433 · protein
IVY:A new family of protein
1UUZ · Inhibitor of vertebrate lysozyme: “IVY:A new family of protein”. X-ray diffraction, 8 pockets (best druggability 0.69). MolNFT v1 #24433 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UUZ
- Type
- protein
- Length
- 514 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Inhibitor of vertebrate lysozyme; Lysozyme C
- EC
- 3.2.1.17
- UniProt
- Q9HXB1, P00698
- Pockets
- 8 · best druggability 0.69
Structure
x-ray diffraction · 4 distinct chains · 33% helix, 19% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Inhibitor of vertebrate lysozyme | protein | 129 | 26% helix, 27% strand | Q9HXB1 |
| B | Inhibitor of vertebrate lysozyme | protein | 128 | 27% helix, 27% strand | Q9HXB1 |
| C | Lysozyme C (EC 3.2.1.17) | protein | 128 | 41% helix, 11% strand | P00698 |
| D | Lysozyme C (EC 3.2.1.17) | protein | 129 | 40% helix, 11% strand | P00698 |
Pockets
8 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 110 | 0.69 | 0.91 | 29 | empty |
| 2 | 162 | 0.65 | 0.86 | 39 | empty |
| 3 | 146 | 0.55 | 0.82 | 29 | empty |
| 4 | 306 | 0.55 | 0.75 | 37 | empty |
| 5 | 127 | 0.43 | 0.77 | 27 | empty |
Interfaces
4 interfaces between chains.
- A–D · 997 Ų buried · 16 hydrogen bonds · protein-protein
- B–C · 994 Ų buried · 18 hydrogen bonds · protein-protein
- A–C · 72 Ų buried · 0 hydrogen bonds · protein-protein
- A–B · 13 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 10 disulfide (disulfide).
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HXB1
- Every structure of UniProt P00698
- Elsewhere: RCSB PDB 1UUZ · PDBe 1UUZ · UniProt Q9HXB1 · UniProt P00698
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.