MolNFT v1 · #24417 · protein

Hyaluronan binding domain of human CD44

1UUH · CD44 antigen: “Hyaluronan binding domain of human CD44”. X-ray diffraction, 2 pockets (best druggability 0.52). MolNFT v1 #24417 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 1UUH
Type: protein
Length: 300 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: CD44 antigen
UniProt: P16070
Pockets: 2 · best druggability 0.52

Structure

x-ray diffraction · 1 distinct chain · 17% helix, 38% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	CD44 antigen	protein	150	17% helix, 38% strand	P16070

Pockets

2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	198	0.52	0.77	37	empty
2	52	0.33	0.78	14	empty

Interfaces

1 interface between chains.

A–B · 588 Å² buried · 10 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 6 disulfide, 4 modified (disulfide, engineered).

Compared structures

1UUH · Hyaluronan binding domain of human CD44 · the same entry in another collection · chain A against A, TM-score 1.00
P16070 · AlphaFold monomer V2.0 prediction for CD44 antigen (P16070) · a predicted model of the same protein · chain B against A, TM-score 0.98

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P16070
Elsewhere: RCSB PDB 1UUH · PDBe 1UUH · UniProt P16070

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