MolNFT v1 · #24264 · protein

Crystal structure of the quorum-sensing protein tram from agrobacterium tumefaciens

1UPG · Transcriptional repressor tram: “Crystal structure of the quorum-sensing protein tram from agrobacterium tumefaciens”. X-ray diffraction, 1 pocket (best druggability 0.58). MolNFT v1 #24264 on GenesisL1: 3D structure, binding sites…

PDB: 1UPG
Type: protein
Length: 189 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Transcriptional repressor tram
UniProt: Q57471
Pockets: 1 · best druggability 0.58

Structure

x-ray diffraction · 2 distinct chains · 69% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Transcriptional repressor tram	protein	90	72% helix, 0% strand	Q57471
B	Transcriptional repressor tram	protein	99	66% helix, 5% strand	Q57471

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	208	0.58	0.80	31	empty

Interfaces

1 interface between chains.

A–B · 1103 Å² buried · 2 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 5 modified (engineered).

Compared structures

1UPG · Crystal structure of the quorum-sensing protein TraM from Agrobacterium tumefaciens · the same entry in another collection · chain A against A, TM-score 1.00
Q57471 · AlphaFold monomer V2.0 prediction for transcriptional repressor tram (Q57471) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q57471
Elsewhere: RCSB PDB 1UPG · PDBe 1UPG · UniProt Q57471

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