MolNFT v1 · #24237 · protein + RNA
Reovirus polymerase lambda-3 localized by electron cryomicroscopy of virions at 7.6-a resolution
1UON · Minor core protein lambda 3: “Reovirus polymerase lambda-3 localized by electron cryomicroscopy of virions at 7.6-a resolution”. Electron microscopy, 2 ligands (CH1, MN), 12 pockets (best druggability 0.85). MolNFT v1 #24237 on…
- PDB
- 1UON
- Type
- protein + RNA
- Length
- 1,277 residues
- Chains
- 3
- Method
- electron microscopy
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Minor core protein lambda 3; 5'-R(*GP*GP*GP*GP*GP*)-3'; 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3'
- UniProt
- P17378
- Ligands
- CH1, MN
- Pockets
- 12 · best druggability 0.85
Structure
electron microscopy · 3 distinct chains · 48% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Minor core protein lambda 3 | protein | 1264 | 48% helix, 13% strand | P17378 |
| B | 5'-R(*GP*GP*GP*GP*GP*)-3' | rna | 5 | — | — |
| C | 5'-R(*UP*AP*GP*CP*CP*CP*CP*CP*)-3' | rna | 8 | — | — |
Ligands and binding sites
- CH1 · 3'-deoxy-cytidine-5'-triphosphate · ligand · 3 copies · chains A, B, C
- MN · Manganese (II) ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
12 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1031 | 0.85 | 0.86 | 121 | CH1, MN |
| 2 | 85 | 0.76 | 0.97 | 27 | empty |
| 3 | 449 | 0.74 | 0.83 | 57 | empty |
| 4 | 452 | 0.73 | 0.83 | 55 | empty |
| 5 | 401 | 0.61 | 0.76 | 41 | CH1 |
Interfaces
3 interfaces between chains.
- A–C · 1073 Ų buried · 17 hydrogen bonds · protein-nucleic
- A–B · 671 Ų buried · 12 hydrogen bonds · protein-nucleic
- B–C · 254 Ų buried · 14 hydrogen bonds · nucleic-nucleic
Compared structures
- 1UON · Reovirus polymerase lambda-3 localized by electron cryomicroscopy of virions at 7.6-a… · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P17378
- Elsewhere: RCSB PDB 1UON · PDBe 1UON · UniProt P17378
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