MolNFT v1 · #2419 · protein
Crystal structure of tyrosine aminotransferase from trypanosoma cruzi
1BW0 · Protein (tyrosine aminotransferase): “Crystal structure of tyrosine aminotransferase from trypanosoma cruzi”. X-ray diffraction, 8 pockets (best druggability 0.72). MolNFT v1 #2419 on GenesisL1: 3D structure, binding sites and…
- PDB
- 1BW0
- Type
- protein
- Length
- 825 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein (tyrosine aminotransferase)
- EC
- 2.6.1.5
- UniProt
- P33447
- Pockets
- 8 · best druggability 0.72
Structure
x-ray diffraction · 2 distinct chains · 43% helix, 16% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein (tyrosine aminotransferase) (EC 2.6.1.5) | protein | 412 | 43% helix, 16% strand | P33447 |
| B | Protein (tyrosine aminotransferase) (EC 2.6.1.5) | protein | 413 | 43% helix, 16% strand | P33447 |
Pockets
8 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 331 | 0.72 | 0.85 | 36 | empty |
| 2 | 344 | 0.70 | 0.83 | 41 | empty |
| 3 | 81 | 0.47 | 0.82 | 18 | empty |
| 4 | 131 | 0.46 | 0.77 | 22 | empty |
| 5 | 85 | 0.42 | 0.79 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3305 Ų buried · 43 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 2 modified (cofactor).
Compared structures
- 1BW0 · Crystal structure of tyrosine aminotransferase from trypanosoma cruzi · the same entry in another collection · chain A against A, TM-score 1.00
- P33447 · AlphaFold monomer V2.0 prediction for tyrosine aminotransferase (P33447) · a predicted model of the same protein · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P33447
- Elsewhere: RCSB PDB 1BW0 · PDBe 1BW0 · UniProt P33447
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