MolNFT v1 · #24164 · protein
Crystal structure of chorismate synthase
1UMF: “Crystal structure of chorismate synthase”. X-ray diffraction, 20 pockets (best druggability 0.91). MolNFT v1 #24164 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UMF
- Type
- protein
- Length
- 1,460 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Chorismate synthase
- EC
- 4.2.3.5
- UniProt
- P56122
- Pockets
- 20 · best druggability 0.91
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Chorismate synthase (EC 4.2.3.5) | protein | 365 | 33% helix, 23% strand | P56122 |
Pockets
20 pockets found on a 1 Å grid, 8 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 979 | 0.91 | 0.94 | 163 | empty |
| 2 | 996 | 0.81 | 0.83 | 77 | empty |
| 3 | 1109 | 0.79 | 0.81 | 105 | empty |
| 4 | 1114 | 0.79 | 0.81 | 90 | empty |
| 5 | 877 | 0.76 | 0.79 | 72 | empty |
Interfaces
6 interfaces between chains.
- A–D · 4130 Ų buried · 61 hydrogen bonds · protein-protein
- B–C · 4041 Ų buried · 61 hydrogen bonds · protein-protein
- A–B · 1486 Ų buried · 19 hydrogen bonds · protein-protein
- C–D · 1460 Ų buried · 17 hydrogen bonds · protein-protein
- B–D · 1448 Ų buried · 15 hydrogen bonds · protein-protein
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P56122
- Elsewhere: RCSB PDB 1UMF · PDBe 1UMF · UniProt P56122
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