MolNFT v1 · #24156 · protein
Catalytic antibody 21H3
1UM6 · Antibody 21H3, L chain: “Catalytic antibody 21H3”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #24156 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UM6
- Type
- protein
- Length
- 436 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Antibody 21H3, L chain; Antibody 21H3, H chain
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 2 distinct chains · 8% helix, 50% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| L | Antibody 21H3, L chain | protein | 219 | 8% helix, 50% strand | — |
| H | Antibody 21H3, H chain | protein | 217 | 8% helix, 50% strand | — |
Pockets
5 pockets found on a 1 Å grid, 3 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 830 | 0.68 | 0.75 | 86 | empty |
| 2 | 59 | 0.62 | 0.92 | 18 | empty |
| 3 | 79 | 0.56 | 0.86 | 17 | empty |
| 4 | 90 | 0.38 | 0.76 | 19 | empty |
| 5 | 65 | 0.27 | 0.72 | 18 | empty |
Interfaces
1 interface between chains.
- L–H · 1842 Ų buried · 23 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1UM6 · catalytic antibody 21h3 · the same entry in another collection · chain L against L, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1UM6 · PDBe 1UM6
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