MolNFT v1 · #24116 · protein
Substrate specificity and assembly of catalytic center derived from two structures of ligated uridylate kinase
1UKY: “Substrate specificity and assembly of catalytic center derived from two structures of ligated uridylate kinase”. X-ray diffraction, 1 ligand (ADP), 1 pocket (best druggability 0.76). MolNFT v1 #24116 on GenesisL1: 3D structure…
- PDB
- 1UKY
- Type
- protein
- Length
- 196 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Uridylate kinase
- EC
- 2.7.4.-
- UniProt
- P15700
- Ligands
- ADP
- Pockets
- 1 · best druggability 0.76
Structure
x-ray diffraction · 1 distinct chain · 56% helix, 13% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Uridylate kinase (EC 2.7.4.-) | protein | 196 | 56% helix, 13% strand | P15700 |
Ligands and binding sites
- ADP · Adenosine-5'-diphosphate · ligand · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 318 | 0.76 | 0.87 | 44 | ADP |
Modifications
Observed in the structure: 1 disulfide (disulfide).
Compared structures
- 1UKY · Substrate specificity and assembly of catalytic center derived from two structures of… · the same entry in another collection · chain A against A, TM-score 1.00
- P15700 · AlphaFold monomer V2.0 prediction for uridylate kinase (P15700) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P15700
- Elsewhere: RCSB PDB 1UKY · PDBe 1UKY · UniProt P15700
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