MolNFT v1 · #24104 · protein
Crystal structure of importin-beta and srebp-2 complex
1UKL · Importin beta-1 subunit: “Crystal structure of importin-beta and srebp-2 complex”. X-ray diffraction, 20 pockets (best druggability 0.79). MolNFT v1 #24104 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UKL
- Type
- protein
- Length
- 1,996 residues
- Chains
- 6
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Importin beta-1 subunit; Sterol regulatory element binding protein-2
- UniProt
- P70168, Q12772
- Pockets
- 20 · best druggability 0.79
Structure
x-ray diffraction · 2 distinct chains · 71% helix, 0% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B | Importin beta-1 subunit | protein | 876 | 71% helix, 0% strand | P70168 |
| C, D, E, F | Sterol regulatory element binding protein-2 | protein | 61 | 70% helix, 0% strand | Q12772 |
Pockets
20 pockets found on a 1 Å grid, 16 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 459 | 0.79 | 0.87 | 70 | empty |
| 2 | 791 | 0.78 | 0.81 | 70 | empty |
| 3 | 1020 | 0.76 | 0.79 | 84 | empty |
| 4 | 265 | 0.71 | 0.86 | 32 | empty |
| 5 | 168 | 0.65 | 0.86 | 34 | empty |
Interfaces
11 interfaces between chains.
- E–F · 1472 Ų buried · 11 hydrogen bonds · protein-protein
- C–D · 1447 Ų buried · 13 hydrogen bonds · protein-protein
- B–E · 952 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 799 Ų buried · 18 hydrogen bonds · protein-protein
- A–D · 772 Ų buried · 10 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 12 modified (engineered).
Compared structures
- 1UKL · Crystal structure of Importin-beta and SREBP-2 complex · the same entry in another collection · chain F against F, TM-score 1.00
- P70168 · AlphaFold monomer V2.0 prediction for importin subunit beta-1 (P70168) · a predicted model of the same protein · chain A against A, TM-score 0.81
- Q12772 · AlphaFold monomer V2.0 prediction for sterol regulatory element- binding protein 2… · a predicted model of the same protein · chain C against A, TM-score 0.81
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P70168
- Every structure of UniProt Q12772
- Elsewhere: RCSB PDB 1UKL · PDBe 1UKL · UniProt P70168 · UniProt Q12772
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.