MolNFT v1 · #24055 · protein
Crystal structure of macrophage migration inhibitory factor from xenopus laevis.
1UIZ: “Crystal structure of macrophage migration inhibitory factor from xenopus laevis.”. X-ray diffraction, 2 pockets (best druggability 0.75). MolNFT v1 #24055 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1UIZ
- Type
- protein
- Length
- 460 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Macrophage migration inhibitory factor
- Pockets
- 2 · best druggability 0.75
Structure
x-ray diffraction · 1 distinct chain · 38% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, B, C, D | Macrophage migration inhibitory factor | protein | 115 | 38% helix, 30% strand | — |
Pockets
2 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 385 | 0.75 | 0.85 | 49 | empty |
| 2 | 187 | 0.54 | 0.79 | 26 | empty |
Interfaces
3 interfaces between chains.
- A–C · 1155 Ų buried · 17 hydrogen bonds · protein-protein
- A–B · 1155 Ų buried · 18 hydrogen bonds · protein-protein
- B–C · 1152 Ų buried · 17 hydrogen bonds · protein-protein
Compared structures
- 1UIZ · Crystal Structure Of Macrophage Migration Inhibitory Factor From Xenopus Laevis. · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1UIZ · PDBe 1UIZ
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