MolNFT v1 · #2405 · protein
Humanized anti-lysozyme fv
1BVL · HULYS11: “Humanized anti-lysozyme fv”. X-ray diffraction, 4 pockets (best druggability 0.44). MolNFT v1 #2405 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1BVL
- Type
- protein
- Length
- 448 residues
- Chains
- 4
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- HULYS11
- Pockets
- 4 · best druggability 0.44
Structure
x-ray diffraction · 2 distinct chains · 4% helix, 47% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, C | HULYS11 | protein | 116 | 5% helix, 47% strand | — |
| B, D | HULYS11 | protein | 108 | 3% helix, 48% strand | — |
Pockets
4 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 184 | 0.44 | 0.74 | 33 | empty |
| 2 | 146 | 0.41 | 0.74 | 25 | empty |
| 3 | 73 | 0.32 | 0.74 | 18 | empty |
| 4 | 70 | 0.29 | 0.74 | 19 | empty |
Interfaces
4 interfaces between chains.
- A–B · 872 Ų buried · 7 hydrogen bonds · protein-protein
- C–D · 845 Ų buried · 10 hydrogen bonds · protein-protein
- B–D · 563 Ų buried · 4 hydrogen bonds · protein-protein
- B–C · 32 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- 1BVL · Humanized anti-lysozyme fv · the same entry in another collection · chain A against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Elsewhere: RCSB PDB 1BVL · PDBe 1BVL
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