MolNFT v1 · #24047 · protein

Crystal structure of polyamine aminopropyltransfease from thermus thermophilus

1UIR · Polyamine aminopropyltransferase: “Crystal structure of polyamine aminopropyltransfease from thermus thermophilus”. X-ray diffraction, 5 pockets (best druggability 0.81). MolNFT v1 #24047 on GenesisL1: 3D structure, binding sites…

PDB: 1UIR
Type: protein
Length: 622 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Polyamine aminopropyltransferase
EC: 2.5.1.16, 2.5.1.22
UniProt: P83816
Pockets: 5 · best druggability 0.81

Structure

x-ray diffraction · 2 distinct chains · 31% helix, 32% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Polyamine aminopropyltransferase (EC 2.5.1.16, 2.5.1.22)	protein	309	31% helix, 32% strand	P83816
B	Polyamine aminopropyltransferase (EC 2.5.1.16, 2.5.1.22)	protein	313	31% helix, 32% strand	P83816

Pockets

5 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	835	0.81	0.84	85	empty
2	433	0.77	0.85	63	empty
3	73	0.73	0.97	17	empty
4	69	0.65	0.93	18	empty
5	56	0.30	0.75	16	empty

Interfaces

1 interface between chains.

A–B · 1838 Å² buried · 21 hydrogen bonds · protein-protein

Compared structures

1UIR · Crystal Structure of Polyamine Aminopropyltransfease from Thermus thermophilus · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P83816
Elsewhere: RCSB PDB 1UIR · PDBe 1UIR · UniProt P83816

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